中文名称:HLA-DPB1 抗原(重组蛋白)
英文名称:HLA-DPB1 Antigen (Recombinant Protein)
别 名:major histocompatibility complex, class II, DP beta 1; DPB1; HLA-DP; HLA-DPB; HLA-DP1B
储 存:冷冻(-20℃)
相关类别:抗原
概述:
Fusion protein corresponding to a region derived from 29-257 amino acids of human HLA-DPB1
技术规格:HLA-DPB1 抗原(重组蛋白)
Full name:
major histocompatibility complex, class II, DP beta 1
Synonyms:
DPB1; HLA-DP; HLA-DPB; HLA-DP1B
Swissprot:
P04440
Gene Accession:
BC015000
Purity:
>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:
Escherichia coli
Tags:
His tag C-Terminus, GST tag N-Terminus
Background:
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
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