CCL-18 在慢性阻塞性肺疾病中的表达

<p>&nbsp;</p> <p>&nbsp;<b>&ldquo;上海酶联文献&rdquo;</b><strong>【摘要】 </strong>目的 比较分析趋化因子配体 -18(CCL-18) 在急性加重期慢性阻塞性肺疾病 ( 慢阻肺 ) 患者治疗前后的表达水平变化情况 , 为患者病情严重程度和临床疗效评价提供依据。方法 急性加重期慢阻肺住院病例 80 例为 A 组 , 稳定期慢阻肺病例 80 例为 B 组 , 健康对照 60 例为 C 组 , A 组患者于入院后 24 h, 治疗后 3、6、9 和 12 d 取血样检测；B 组患者于病情稳定后 24 h 取血样检测；C 组于体检时取血样 , 采用酶联免疫吸附法测定 CCL-18 和白细胞介素 -6(IL-6) 值。结果 A 组入院后 24 h, A 组 CCL-18和 IL-6 显著高于 B、C 组 (P&lt;0.01), B 组显著高于 C 组 (P&lt;0.01)。随着治疗的进行 , A 组患者 CCL-18和 FEV1% 预计值逐渐下降 , 以 CCL-18 为自变量 , 以 FEV1% 预计值为因变量进行一元回归分析 , 证实两种变量间存在负相关：r=-0.991, Y=126.599-9.714X(P&lt;0.01)。结论 CCL-18 在慢阻肺患者中呈高表达 ,随着患者病情的加重 , CCL-18 表达增高 , 且其表达与患者肺功能呈负相关性。</p> <p>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<span style="font-family:Arial;font-size:9.0000pt;">表&nbsp;</span><!--[endif]--><span style="mso-spacerun:'yes';font-family:Arial;font-size:9.0000pt;">1 &nbsp;</span><span style="mso-spacerun:'yes';font-family:宋体;font-size:9.0000pt;">三组</span><span style="mso-spacerun:'yes';font-family:Arial;font-size:9.0000pt;">&nbsp;CCL-18 </span><span style="mso-spacerun:'yes';font-family:宋体;font-size:9.0000pt;">和</span><span style="mso-spacerun:'yes';font-family:Arial;font-size:9.0000pt;">&nbsp;IL-6 </span><span style="mso-spacerun:'yes';font-family:宋体;font-size:9.0000pt;">水平比较</span><span style="mso-spacerun:'yes';font-family:Arial;font-size:9.0000pt;">&nbsp;( </span>^{<span style="mso-spacerun:'yes';font-family:Arial;font-size:18.0000pt;vertical-align:super;">-</span>}<span style="mso-spacerun:'yes';font-family:Arial;font-size:9.0000pt;">x&plusmn;s)</span><span style="mso-spacerun:'yes';font-family:宋体;font-size:9.0000pt;"><o:p></o:p></span></p> <table class="MsoNormalTable" border="0" cellspacing="0" style="border-collapse: collapse; width: 488pt; margin-left: 8.4pt; border-width: initial; border-style: none; border-color: initial;"> <tbody> <tr style="height:9.9000pt;"> <td width="162" valign="bottom" style="width:122.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:1.0000pt solid windowtext;mso-border-top-alt:1.0000pt solid windowtext;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal" align="center" style="text-align:center;line-height:9.1500pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:宋体;font-size:8.0000pt;">组别</span><span style="font-family:宋体;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="152" valign="bottom" style="width:114.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:1.0000pt solid windowtext;mso-border-top-alt:1.0000pt solid windowtext;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal" align="center" style="margin-left:4.0000pt;text-align:center;line-height:9.1500pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:宋体;font-size:8.0000pt;">例数</span><span style="font-family:宋体;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="177" valign="bottom" style="width:133.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:1.0000pt solid windowtext;mso-border-top-alt:1.0000pt solid windowtext;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal" style="margin-left:44.0000pt;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">CCL-18(ng/ml)</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="158" valign="bottom" style="width:119.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:1.0000pt solid windowtext;mso-border-top-alt:1.0000pt solid windowtext;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal" align="right" style="margin-right:40.0000pt;text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">IL-6(ng/L)</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> </tr> <tr style="height:9.7500pt;"> <td width="162" valign="bottom" style="width:122.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="center" style="text-align:center;line-height:9.7000pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">A </span><span style="font-family:宋体;font-size:8.0000pt;">组</span><span style="font-family:宋体;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="152" valign="bottom" style="width:114.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="center" style="margin-left:4.0000pt;text-align:center;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">80</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="177" valign="bottom" style="width:133.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="center" style="margin-left:1.0000pt;text-align:center;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">8.2&plusmn;0.8</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="158" valign="bottom" style="width:119.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="right" style="margin-right:41.0000pt;text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">11.8&plusmn;1.3</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> </tr> <tr style="height:10.8500pt;"> <td width="162" valign="bottom" style="width:122.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="center" style="text-align:center;line-height:9.7000pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">B </span><span style="font-family:宋体;font-size:8.0000pt;">组</span><span style="font-family:宋体;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="152" valign="bottom" style="width:114.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="center" style="margin-left:4.0000pt;text-align:center;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">80</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="177" valign="bottom" style="width:133.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="center" style="margin-left:1.0000pt;text-align:center;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">5.7&plusmn;0.8</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="158" valign="bottom" style="width:119.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="right" style="margin-right:41.0000pt;text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">9.6&plusmn;1.5</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> </tr> <tr style="height:10.0500pt;"> <td width="162" valign="bottom" style="width:122.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="center" style="text-align:center;line-height:9.7000pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">C </span><span style="font-family:宋体;font-size:8.0000pt;">组</span><span style="font-family:宋体;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="152" valign="bottom" style="width:114.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="center" style="margin-left:4.0000pt;text-align:center;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">60</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="177" valign="bottom" style="width:133.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="center" style="margin-left:1.0000pt;text-align:center;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">3.4&plusmn;0.3</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="158" valign="bottom" style="width:119.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="right" style="margin-right:41.0000pt;text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">8.5&plusmn;1.2</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> </tr> <tr style="height:10.8500pt;"> <td width="162" valign="bottom" style="width:122.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="center" style="text-align:center;mso-line-height-alt:0pt;"><span style="font-family:Arial;font-size:8.0000pt;">F</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="152" valign="bottom" style="width:114.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:9.0000pt;">&nbsp;</span></p> </td> <td width="177" valign="bottom" style="width:133.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="center" style="margin-left:1.0000pt;text-align:center;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">12.473</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="158" valign="bottom" style="width:119.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="right" style="margin-right:48.0000pt;text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">7.896</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> </tr> <tr style="height:12.1000pt;"> <td width="162" valign="bottom" style="width:122.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="center" style="text-align:center;mso-line-height-alt:0pt;"><span style="font-family:Arial;font-size:8.0000pt;">P</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="152" valign="bottom" style="width:114.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal"><span style="font-family:'Times New Roman';font-size:10.5000pt;">&nbsp;</span></p> </td> <td width="177" valign="bottom" style="width:133.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="center" style="margin-left:1.0000pt;text-align:center;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">&lt;0.01</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="158" valign="bottom" style="width:119.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="right" style="margin-right:48.0000pt;text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">&lt;0.01</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> </tr> </tbody> </table> <p class="MsoNormal" style="line-height:1.0000pt;mso-line-height-rule:exactly;"><span style="position:absolute;z-index:-1;margin-left:4.0000px;margin-top:-0.0667px;width:652.0000px;height:1.0000px;"><img width="652" height="1" src="file:///C:\Users\ADMINI~1\AppData\Local\Temp\ksohtml\wpsB9D0.tmp.png" alt="" /></span><span style="mso-spacerun:'yes';font-family:'Times New Roman';">&nbsp;</span></p> <p class="MsoNormal" style="margin-left:17.0000pt;line-height:9.2000pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:宋体;font-size:8.0000pt;">注：三组比较</span><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">&nbsp;, P&lt;0.01</span><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> <p class="MsoNormal" style="margin-left:109.0000pt;text-indent:-10.8000pt;line-height:16.2500pt;mso-line-height-rule:exactly;mso-list:l1 level1 lfo2;"><!--[if !supportLists]--><span style="font-family:Arial;font-size:9.0000pt;">表&nbsp;</span><!--[endif]--><span style="mso-spacerun:'yes';font-family:Arial;font-size:9.0000pt;">2 &nbsp;A </span><span style="mso-spacerun:'yes';font-family:宋体;font-size:9.0000pt;">组患者治疗不同时间点的</span><span style="mso-spacerun:'yes';font-family:Arial;font-size:9.0000pt;">&nbsp;CCL-18 </span><span style="mso-spacerun:'yes';font-family:宋体;font-size:9.0000pt;">与</span><span style="mso-spacerun:'yes';font-family:Arial;font-size:9.0000pt;">&nbsp;FEV1% </span><span style="mso-spacerun:'yes';font-family:宋体;font-size:9.0000pt;">预计值变化水平</span><span style="mso-spacerun:'yes';font-family:Arial;font-size:9.0000pt;">&nbsp;( </span>^{<span style="mso-spacerun:'yes';font-family:Arial;font-size:18.0000pt;vertical-align:super;">-</span>}<span style="mso-spacerun:'yes';font-family:Arial;font-size:9.0000pt;">x&plusmn;s)</span><span style="mso-spacerun:'yes';font-family:宋体;font-size:9.0000pt;"><o:p></o:p></span></p> <table class="MsoNormalTable" border="0" cellspacing="0" style="border-collapse: collapse; width: 488pt; margin-left: 8.4pt; border-width: initial; border-style: none; border-color: initial;"> <tbody> <tr style="height:9.9000pt;"> <td width="116" valign="bottom" style="width:87.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:1.0000pt solid windowtext;mso-border-top-alt:1.0000pt solid windowtext;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal" align="center" style="margin-right:1.0000pt;text-align:center;line-height:9.1500pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:宋体;font-size:8.0000pt;">指标</span><span style="font-family:宋体;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="102" valign="bottom" style="width:77.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:1.0000pt solid windowtext;mso-border-top-alt:1.0000pt solid windowtext;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal" align="right" style="margin-right:18.0000pt;text-align:right;line-height:9.7000pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:宋体;font-size:8.0000pt;">入院后</span><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">&nbsp;24 h</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="106" valign="bottom" style="width:80.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:1.0000pt solid windowtext;mso-border-top-alt:1.0000pt solid windowtext;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal" align="right" style="margin-right:19.0000pt;text-align:right;line-height:9.7000pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:宋体;font-size:8.0000pt;">治疗后</span><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">&nbsp;3 d</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="108" valign="bottom" style="width:81.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:1.0000pt solid windowtext;mso-border-top-alt:1.0000pt solid windowtext;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal" align="right" style="margin-right:19.0000pt;text-align:right;line-height:9.7000pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:宋体;font-size:8.0000pt;">治疗后</span><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">&nbsp;6 d</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="106" valign="bottom" style="width:80.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:1.0000pt solid windowtext;mso-border-top-alt:1.0000pt solid windowtext;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal" align="right" style="margin-right:17.0000pt;text-align:right;line-height:9.7000pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:宋体;font-size:8.0000pt;">治疗后</span><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">&nbsp;9 d</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="110" valign="bottom" style="width:83.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:1.0000pt solid windowtext;mso-border-top-alt:1.0000pt solid windowtext;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal" align="right" style="margin-right:17.0000pt;text-align:right;line-height:9.7000pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:宋体;font-size:8.0000pt;">治疗后</span><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">&nbsp;12 d</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> </tr> <tr style="height:9.7500pt;"> <td width="116" valign="bottom" style="width:87.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" style="margin-left:16.0000pt;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">CCL-18(ng/ml)</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="102" valign="bottom" style="width:77.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="right" style="margin-right:22.0000pt;text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">8.2&plusmn;0.8</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="106" valign="bottom" style="width:80.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="right" style="margin-right:21.0000pt;text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">7.1&plusmn;0.5</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="108" valign="bottom" style="width:81.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="right" style="margin-right:21.0000pt;text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">6.3&plusmn;0.7</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="106" valign="bottom" style="width:80.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="right" style="margin-right:19.0000pt;text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">5.9&plusmn;0.7</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="110" valign="bottom" style="width:83.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:none;"> <p class="MsoNormal" align="right" style="margin-right:21.0000pt;text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">5.7&plusmn;0.8</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> </tr> <tr style="height:10.8500pt;"> <td width="116" valign="bottom" style="width:87.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal" align="center" style="margin-right:1.0000pt;text-align:center;line-height:9.7000pt;mso-line-height-rule:exactly;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">FEV1% </span><span style="mso-spacerun:'yes';font-family:宋体;font-size:8.0000pt;">预计值</span><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">&nbsp;(%)</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="102" valign="bottom" style="width:77.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal" align="right" style="margin-right:22.0000pt;text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">47.9&plusmn;9.6</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="106" valign="bottom" style="width:80.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal" align="right" style="margin-right:21.0000pt;text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">56.6&plusmn;8.2</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="108" valign="bottom" style="width:81.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal" align="right" style="margin-right:21.0000pt;text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">63.8&plusmn;7.3</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="106" valign="bottom" style="width:80.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal" align="right" style="margin-right:19.0000pt;text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">69.4&plusmn;7.8</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> <td width="110" valign="bottom" style="width:83.0000pt;padding:0.0000pt 0.0000pt 0.0000pt 0.0000pt ;border-left:none;border-right:none;border-top:none;border-bottom:1.0000pt solid windowtext;mso-border-bottom-alt:1.0000pt solid windowtext;"> <p class="MsoNormal" align="right" style="margin-right:21.0000pt;text-align:right;mso-line-height-alt:0pt;"><span style="mso-spacerun:'yes';font-family:Arial;font-size:8.0000pt;">72.8&plusmn;7.6</span><span style="font-family:Arial;font-size:8.0000pt;"><o:p></o:p></span></p> </td> </tr> </tbody> </table> <p>&nbsp;</p> <p>&nbsp;</p> <p>早期的研究发现 , CCL-18 在肺内呈现持续的高表达 , 而在淋巴组织、胸腺、阑尾等组织中则呈低表达。近些年来 , 我国临床逐渐出现肺部疾病的 CCL-18 表达的相关研究 , 刘桂桃等［14］通过动物实验证实了 CCL-18 参与肺纤维化的发生过程；王健等［15］的临床报道证实了 CCL-18 在过敏性哮喘急性发作期中的高表达特征。</p> <p><img src="/images/upload/Image/QQ图片20180710155811(1).png" width="308" height="179" alt="" /></p>